What is the most likely diagnosis and why? Answer Retinoblastoma. The specimen shows an intense dark staining of the disorganised retina. The dark staining is due to the high concentration of DNA within the tumour. The DNA frequently leaks out of retinoblastoma cells and give the surrounding structure a basophilic staining. (Note: if the retinoblastoma has significant necrosis, the staining may be pinkish ie.eosinophilic rather than basophilic) What tests may be useful in assissting the diagnosis? a Answer CT scan or ultrasound B scan. Calcification is a common feature of retinoblastoma which is absent in most other conditions included in the differential diagnosis of retinoblastoma..
What is the prognosis of this patient based on the specimen above?a Answer Poor. The optic nerve shows tumour invasion. The prognosis is especially poor if the section margin shows the presence of tumour.
