What does the specimen and what is the most likely diagnosis? Answer The optic nerve shows a fusiform mass. As the specimen was taken from a child, the most likely diagnosis is optic glioma. a How can the biopsy of this lesion be confused with meningioma? a Answer Optic nerve glioma can cause overlying meningeal hyperplasia. Biopsy of this area can cause confusion with meningioma. Which inherited condition is associated with this lesion? a AnswerType I neurofibromatosis.