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Fly mushroom
(Amanita
muscaria) contains the neurotoxin
muscarine which makes it poisonous. The infusions of
the
mushroom are used as intoxicating drink in Siberia. Muscarine
was first isolated in 1869. Topical application causes
miosis,
ciliary muscle contraction and lacrimation. Ophthalmic
use of
muscarine never becomes popular because of the difficulty
of
isolating the alkaloid in it pure form and also the highly
toxic
systemic effects. |
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